ITCHINESS

Itchiness experienced by people need to be sorted out fast if not people will start scratching and this causes bruises and other problems. ITCH CREAM is an advanced natural topical anti-itch cream for dry and itchy skin treatment. Standardized bio actives in this allergy rash cream can penetrate deep into the skin layers to relieve skin irritation and inflammation which can be caused by allergic reactions or insect bites.

Unlike hydro cortisone cream that mainly made from steroid to treat inflammation of the skin, this anti-itch treatment cream only uses natural advanced plant-based actives to effectively and safely calm and soothes irritation on the skin. Its function not only limited as a remedy for itchy skin, but it also prevents dead skin build-up by sloughing off flaky and dry skin effectively

ITCH CREAM is advanced plant based formulation for calming irritated and itchy skin.

SYMPTOMS OF ITCHINESS
Itchy skin may occur over certain small areas, such as on the arm or leg, or over the whole body. Itchy skin can occur without any other noticeable changes on the skin. Or it may be associated with:

• Redness
• Bumps, spots or blisters
• Dry, cracked skin
• Leathery or scaly texture to the skin

Sometimes itchiness lasts a long time and can be intense. Rubbing or scratching the area will cause much itchier. And the more it itches, the more scratching will be. Breaking this itch-scratch cycle can be difficult, but continued scratching can damage the skin or cause infection.

RESULT/ DISADVANTAGE/ DRAWBACK OF ITCHINESS

Itching is an uncomfortable sensation in the skin that feels as if something is crawling on the skin and makes the person want to scratch the affected area. Repeated scratching can cause raised, thickened areas of skin that may bleed or become infected. Itching is medically known as purities and something that is itchy is called pruritic. Itching can be diffuse which are generalized all over the body or localized which means all over or confined to a specific spot. Sometimes cramping and blistering accompany the itching. Boost your immune system because this will hinder diseases or conditions associated with oxidative stresses and others.

Mast cells remain inactive until an allergen binds to IgE already coated upon the cell. The allergen binds to the antigen-binding sites, which are situated on the variable regions of the IgE molecules bound to the mast cell surface. IgE binds to receptor on mast cells, leading to degranulation of mast cells and causing typical allergic symptom such as itching.
The allergic immune response is directed against various environmental allergens. A tendency to develop T helper type-2 (Th2) immune response is prominent in atopic individuals under the influence of genes and microenvironment. Subsets of immune and inflammatory cells interact through cytokines. The cytokines responsible for the allergic response include interleukin (IL) 4, IL-13, and IL-54).

Specific recognition of antigenic determinants (epitopes) of allergens by T and B lymphocytes elicits the immune response. The recognition is controlled by highly specialized antigen-presenting cells located in strategic position, such as the dermis. Processing and presenting allergenic epitopes to T-helper (Th) lymphocytes in the presence of relevant cytokines, chemokines, signals, vitamins, histamine-adenosine-like small molecules, and other cells in the micro milieu shape the immune response.

In the presence of IL-4, naive T cells activated by antigen-presenting cells differentiate into Th2 cells. In the presence of IL-4 and IL-13, class-switching in B cells promotes the synthesis of IgE antibodies. Allergen-specific IgE antibodies bind to the high-affinity IgE (FcεRI) receptors that are expressed on mast cells and basophils. Re-exposure to the sensitizing allergen activates mast cells and basophils to produce and release biogenic mediators (histamine, proteases, and newly generated lipid-derived mediators, such as leukotrienes and cytokines) that are responsible for the symptoms and signs of type-1 hypersensitivity allergic reactions.

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